Carlei F, Caruso U, Lezoche E, Ruscitto G, Lackie P, Casciani U, Speranza V, Polak J M
Digestion. 1984;29(1):26-30. doi: 10.1159/000199004.
In this study we have performed a quantitative analysis of antral gastrin cells in 9 uraemic patients under dialytic treatment compared to a group of 10 chronic gastritis patients with a similar histological degree of gastritis. Immunocytochemistry was carried out on endoscopic biopsies of both groups. Using a computerised image analysing system we showed a significant increase of G-cell density (number of cells/mm2) in uraemic patients compared to non-uraemics (p less than 0.001). These findings provide a further morphological basis for the elevation of gastrin levels in chronic uraemic patients, suggesting the existence of a specific factor inducing G-cell proliferation in these patients.
在本研究中，我们对9例接受透析治疗的尿毒症患者的胃窦胃泌素细胞进行了定量分析，并与10例具有相似胃炎组织学程度的慢性胃炎患者组成的对照组进行了比较。对两组患者均进行了内镜活检的免疫细胞化学检测。使用计算机图像分析系统，我们发现与非尿毒症患者相比，尿毒症患者的G细胞密度（细胞数/mm²）显著增加（p<0.001）。这些发现为慢性尿毒症患者胃泌素水平升高提供了进一步的形态学依据，提示这些患者中存在诱导G细胞增殖的特定因素。
