Jones P G, Kauffman C A, Bergman A G, Hayes C M, Kluger M J, Cannon J G
Gerontology. 1984;30(3):182-7. doi: 10.1159/000212627.
In an attempt to explain the diminished febrile response of the elderly, we studied the first step in fever generation, that of production of leukocytic pyrogen (LP) by monocytes. Monocytes from 25 healthy elderly volunteers (ages 65-91) and 24 healthy young volunteers (ages 17-38) were stimulated with Staphylococcus epidermidis to release LP; LP activity in the culture supernatants was assayed by measuring the pyrogenic response in rabbits and rats and the fall in plasma iron and zinc in rats. Monocytes from elderly volunteers produced slightly less LP than monocytes from young volunteers, but the difference was not statistically significant. The amount of LP produced was not correlated with age. Therefore, the diminished febrile response of the elderly is not the result of an intrinsic defect in the monocyte's ability to make LP. Other explanations relating to the central effect of LP and the effector response to LP in the elderly should be sought.
为了解释老年人发热反应减弱的原因，我们研究了发热产生的第一步，即单核细胞产生白细胞致热原（LP）的过程。用表皮葡萄球菌刺激25名健康老年志愿者（年龄65 - 91岁）和24名健康年轻志愿者（年龄17 - 38岁）的单核细胞以释放LP；通过测量兔和大鼠的发热反应以及大鼠血浆中铁和锌的下降来检测培养上清液中的LP活性。老年志愿者的单核细胞产生的LP略少于年轻志愿者的单核细胞，但差异无统计学意义。产生的LP量与年龄无关。因此，老年人发热反应减弱并非单核细胞产生LP能力的内在缺陷所致。应寻找与LP在老年人中的中枢效应以及对LP的效应反应相关的其他解释。
