Jones P G, Kauffman C A, Port F K, Kluger M J
Am J Kidney Dis. 1985 Oct;6(4):241-4. doi: 10.1016/s0272-6386(85)80180-3.
Uremic patients frequently have low baseline temperatures and a blunted febrile response to infection. We investigated the first step in the generation of a febrile response, the production of leukocytic pyrogen (LP) by blood monocytes, in 12 patients on chronic hemodialysis, five patients on continuous ambulatory peritoneal dialysis (CAPD), and 17 control subjects. No significant differences were found in the amount of LP produced by hemodialysis patients, CAPD patients, and control subjects. Uremic serum did not decrease LP production by monocytes from control subjects. Hemodialysis patients who were consistently hypothermic (mean oral predialysis temperature less than or equal to 35.6 degrees F) produced as much LP as those with more normal oral temperatures (mean oral predialysis temperature greater than or equal to 36.8 degrees F). Decreased production of LP does not explain the blunted febrile response noted in patients with chronic renal failure.
尿毒症患者常常基线体温较低，对感染的发热反应迟钝。我们研究了发热反应产生的第一步，即血液单核细胞产生白细胞热原（LP）的情况，研究对象包括12例接受慢性血液透析的患者、5例接受持续性非卧床腹膜透析（CAPD）的患者以及17名对照者。血液透析患者、CAPD患者和对照者产生的LP量未发现显著差异。尿毒症血清并未降低对照者单核细胞产生LP的量。体温持续过低（透析前平均口腔温度小于或等于35.6华氏度）的血液透析患者产生的LP与口腔温度较为正常（透析前平均口腔温度大于或等于36.8华氏度）的患者一样多。LP产生减少并不能解释慢性肾衰竭患者出现的发热反应迟钝现象。
