Haudenschild C C, Chobanian A V
Hypertension. 1984 Mar-Apr;6(2 Pt 2):I62-8. doi: 10.1161/01.hyp.6.2_pt_2.i62.
These studies were undertaken to determine whether age-related changes in the aortic intima can be inhibited by prolonged blood pressure lowering. Normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were treated with a combination of chlorothiazide, reserpine, and hydralazine beginning at 20 weeks of age and continuing until 62 weeks. Aortic morphology was assessed at the termination of the study by light and electron microscopy. Average systolic blood pressures during the final 6 months of therapy were: for untreated WKY, 147 +/- 5 mm Hg (mean +/- SE); for treated WKY, 110 +/- 2; for untreated SHR, 206 +/- 3; and for treated SHR, 104 +/- 4. Intimal and medial abnormalities were maximal in untreated SHR, while untreated WKY showed moderate changes consistent with their age. In contrast, both treatment groups exhibited relatively minimal alterations despite their advanced age. The occurrence of intimal lesions in individual animals correlated with the average level of blood pressure during therapy. These data suggest that blood pressure reduction, even in normotensive animals, may reduce the effects of aging on the arterial wall.
进行这些研究是为了确定长期降低血压是否能够抑制主动脉内膜与年龄相关的变化。正常血压的Wistar-Kyoto大鼠（WKY）和自发性高血压大鼠（SHR）从20周龄开始接受氯噻嗪、利血平和肼苯哒嗪联合治疗，持续至62周。在研究结束时通过光学显微镜和电子显微镜评估主动脉形态。治疗最后6个月期间的平均收缩压分别为：未治疗的WKY为147±5 mmHg（平均值±标准误）；治疗后的WKY为110±2；未治疗的SHR为206±3；治疗后的SHR为104±4。未治疗的SHR内膜和中膜异常最为严重，而未治疗的WKY表现出与年龄相符的中度变化。相比之下，尽管两组治疗动物年龄较大，但内膜变化相对较小。个体动物内膜病变的发生与治疗期间的平均血压水平相关。这些数据表明，即使在正常血压的动物中，降低血压也可能减轻衰老对动脉壁的影响。
