• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Development of optimal drug administration strategies for cancer-chemotherapy in the framework of systems theory.

作者信息

Acharya R S, Sundareshan M K

出版信息

Int J Biomed Comput. 1984 Mar-Apr;15(2):139-50. doi: 10.1016/0020-7101(84)90026-6.

DOI:10.1016/0020-7101(84)90026-6
PMID:6724730
Abstract

Design of Drug administration strategies for cancer chemotherapy is formulated as an optimization problem by considering both the healthy (normal) and tumor cell kinetics. The optimization problem is solved by using concepts of exponential stabilization and an algorithm for the solution of the above problem is presented.

摘要

相似文献

1
Development of optimal drug administration strategies for cancer-chemotherapy in the framework of systems theory.
Int J Biomed Comput. 1984 Mar-Apr;15(2):139-50. doi: 10.1016/0020-7101(84)90026-6.
2
Role of optimal control theory in cancer chemotherapy.
Math Biosci. 1990 Oct;101(2):237-84. doi: 10.1016/0025-5564(90)90021-p.
3
Development of optimal drug administration strategies for cancer - chemotherapy in the framework of systems theory.基于系统理论框架的癌症化疗最佳给药策略的开发。
Biomed Sci Instrum. 1983;19:71-6.
4
Some optimal control problems in cancer chemotherapy with a toxicity limit.具有毒性限制的癌症化疗中的一些最优控制问题。
Math Biosci. 1990 Jun;100(1):49-67. doi: 10.1016/0025-5564(90)90047-3.
5
Conflicting objectives in chemotherapy with drug resistance.化疗中耐药性带来的目标冲突。
Bull Math Biol. 1997 Jul;59(4):707-24. doi: 10.1007/BF02458426.
6
Optimal drug regimens in cancer chemotherapy for single drugs that block progression through the cell cycle.癌症化疗中用于阻断细胞周期进展的单一药物的最佳用药方案。
Math Biosci. 1994 Oct;123(2):183-213. doi: 10.1016/0025-5564(94)90011-6.
7
Drug kinetics and drug resistance in optimal chemotherapy.最佳化疗中的药物动力学与耐药性
Math Biosci. 1995 Feb;125(2):191-209. doi: 10.1016/0025-5564(94)00027-w.
8
A mathematical model of periodically pulsed chemotherapy: tumor recurrence and metastasis in a competitive environment.周期性脉冲化疗的数学模型：竞争环境中的肿瘤复发与转移
Bull Math Biol. 1996 May;58(3):425-47. doi: 10.1007/BF02460591.
9
Mathematical approaches to optimization of cancer chemotherapy.癌症化疗优化的数学方法。
Bull Math Biol. 1979;41(3):305-24. doi: 10.1007/BF02460814.
10
Chemotherapeutic treatments involving drug resistance and level of normal cells as a criterion of toxicity.以耐药性和正常细胞水平作为毒性标准的化疗治疗。
Math Biosci. 1995 Feb;125(2):211-28. doi: 10.1016/0025-5564(94)00028-x.

引用本文的文献

1
Mathematical modeling of tumor-immune dynamics: stability, control, and synchronization via fractional calculus and numerical optimization.肿瘤免疫动力学的数学建模：通过分数阶微积分和数值优化实现稳定性、控制与同步
Sci Rep. 2025 Aug 8;15(1):29094. doi: 10.1038/s41598-025-13683-z.
2
A Novel Scheme for Optimal Control of a Nonlinear Delay Differential Equations Model to Determine Effective and Optimal Administrating Chemotherapy Agents in Breast Cancer.一种用于非线性延迟微分方程模型最优控制的新方案，以确定乳腺癌中有效和最优的化疗药物给药方式。
Iran J Cancer Prev. 2011 Fall;4(4):154-62.
3
An integrated disease/pharmacokinetic/pharmacodynamic model suggests improved interleukin-21 regimens validated prospectively for mouse solid cancers.
一个整合的疾病/药代动力学/药效动力学模型表明，为鼠类实体瘤前瞻性验证的白细胞介素-21 方案得到了改善。
PLoS Comput Biol. 2011 Sep;7(9):e1002206. doi: 10.1371/journal.pcbi.1002206. Epub 2011 Sep 29.
4
Predicting outcomes of prostate cancer immunotherapy by personalized mathematical models.通过个性化的数学模型预测前列腺癌免疫治疗的结果。
PLoS One. 2010 Dec 8;5(12):e15482. doi: 10.1371/journal.pone.0015482.
5
Nano to micro delivery systems: targeting angiogenesis in brain tumors.纳米至微米级递送系统：靶向脑肿瘤中的血管生成
J Angiogenes Res. 2010 Oct 8;2(1):20. doi: 10.1186/2040-2384-2-20.