Murray J M
School of Mathematics, University of New South Wales, Kensington, Australia.
Math Biosci. 1994 Oct;123(2):183-213. doi: 10.1016/0025-5564(94)90011-6.
In this paper we study the application of a single drug in cancer chemotherapy where the drug can block progression through the cell cycle. Under certain conditions we determine the regimen that reduces the tumor population to a desired endpoint in minimal time while keeping a normal cell population above some lower limit. We also study the sensitivity of the optimal solution to various parameters.
在本文中，我们研究了单一药物在癌症化疗中的应用，该药物可阻断细胞周期进程。在某些条件下，我们确定了一种治疗方案，该方案能在最短时间内将肿瘤细胞数量减少到预期终点，同时使正常细胞数量保持在某个下限之上。我们还研究了最优解对各种参数的敏感性。
