Mitchell A J, Anderson T F, Headington J T, Rasmussen J E
Int J Dermatol. 1984 Apr;23(3):198-202. doi: 10.1111/j.1365-4362.1984.tb04511.x.
A 27-year-old woman developed a chronic, recurrent eruption of the face and upper extremities with the clinical and histopathologic features of recurrent granulomatous dermatitis with eosinophilia (Wells' syndrome). As described in 15 previously reported cases, this disorder is characterized by two clinical phases (eosinophilic cellulitis and granulomatous plaque phase) and three histopathologic stages. The latter are particularly remarkable for a diffuse dermal and subcutaneous eosinophilia in acute lesions and scattered flame figures in chronic lesions. Distinctive findings in this case were the predominance of facial involvement and the symptomatic response to topical corticosteroids. Although etiology and pathogenesis are unknown, we feel that Wells' syndrome is a unique yet rarely recognized clinicopathologic entity.
一名27岁女性面部和上肢出现慢性复发性皮疹，具有复发性嗜酸性粒细胞性肉芽肿性皮炎（韦尔斯综合征）的临床和组织病理学特征。如之前报道的15例病例所述，该疾病具有两个临床阶段（嗜酸性粒细胞性蜂窝织炎和肉芽肿性斑块期）和三个组织病理学阶段。后者在急性病变中以弥漫性真皮和皮下嗜酸性粒细胞增多以及慢性病变中散在的火焰状图形尤为显著。该病例的独特发现是面部受累为主以及对局部皮质类固醇有症状反应。尽管病因和发病机制尚不清楚，但我们认为韦尔斯综合征是一种独特但很少被认识的临床病理实体。
