Stradling G N, Stather J W, Sumner S A, Moody J C, Strong J C
Health Phys. 1984 Jun;46(6):1296-300.
Accidental intakes of 241AmO2 and 241Am(NO3)3 can be treated with some success by inhalation of ZnDTPA . The main advantage of this method of treatment is that it can be self-administered very soon after an accidental intake, and it is effective for reducing the lung content of Am at doses about 10 times less than those usually used intravenously. Otherwise the efficacy of injected ZnDTPA is superior since in addition to removing 241Am from the lungs it can deplete appreciably the systemic deposit of the nuclide. There appears to be no advantage in using the lipophilic form of DTPA code-named Puchel , since following the inhalation or injection of the compound decorporation is not significantly increased relative to ZnDTPA .
意外摄入二氧化镅-241和硝酸镅-241后，吸入二乙三胺五乙酸锌（ZnDTPA）可取得一定的治疗效果。这种治疗方法的主要优点是，在意外摄入后很快就能自行给药，而且在剂量比通常静脉注射剂量低约10倍的情况下，对降低肺部镅含量有效。否则，注射用ZnDTPA的疗效更优，因为它除了能从肺部清除241Am外，还能显著减少该核素在全身的沉积。使用代号为Puchel的亲脂性二乙三胺五乙酸（DTPA）形式似乎没有优势，因为吸入或注射该化合物后，相对于ZnDTPA，促排效果并没有显著提高。
