Després J P, Bouchard C, Savard R, Tremblay A, Marcotte M, Thériault G
J Appl Physiol Respir Environ Exerc Physiol. 1984 May;56(5):1157-61. doi: 10.1152/jappl.1984.56.5.1157.
The present experiment was conducted to study the influence of exercise training on adipose tissue lipolytic activity and to identify the amount of training required to induce maximal adaptation in humans. Fifty-one male subjects were divided into three groups according to their training regimen: 1) sedentary subjects (SS) (n = 21); 2) trained subjects (TS) (n = 15) who had exercised during a period of 20 wk, 5 days/wk, 45 min/session; and 3) experienced marathon runners (MR) (n = 15) who ran an average of 120 km/wk for many years. Biopsies of fat were performed in the suprailiac region after an overnight fast. Adipocyte diameter (AD) and epinephrine-stimulated lipolysis ( ESL ) were assessed on collagenase-isolated fat cells. A lower AD was noted in the MR group compared with the two other groups. Basal lipolysis (BL) and ESL were significantly higher in TS and MR than in controls. Moreover, BL values were comparable in the two trained groups, whereas ESL in the TS group was higher than in the MR group. These results indicate that training increases suprailiac fat cell lipolysis, which seems to adapt maximally within about 4 mo.
本实验旨在研究运动训练对脂肪组织脂解活性的影响，并确定在人类中诱导最大适应性所需的训练量。51名男性受试者根据其训练方案分为三组：1）久坐不动的受试者（SS）（n = 21）；2）训练有素的受试者（TS）（n = 15），他们在20周内每周训练5天，每次训练45分钟；3）经验丰富的马拉松跑者（MR）（n = 15），多年来平均每周跑120公里。在禁食过夜后，在髂上区域进行脂肪活检。在胶原酶分离的脂肪细胞上评估脂肪细胞直径（AD）和肾上腺素刺激的脂解作用（ESL）。与其他两组相比，MR组的AD较低。TS组和MR组的基础脂解（BL）和ESL显著高于对照组。此外，两组训练有素的受试者的BL值相当，而TS组的ESL高于MR组。这些结果表明，训练可增加髂上脂肪细胞的脂解作用，其似乎在约4个月内达到最大适应。
