Fujita K
J Antibiot (Tokyo). 1984 Apr;37(4):408-12. doi: 10.7164/antibiotics.37.408.
The effect on amikacin pharmacokinetics by fosfomycin previously or simultaneously administered via the intraperitoneal, intramuscular, or oral route was studied in the rats. Absorption of amikacin from the peritoneal cavity was prolonged by co-administered fosfomycin. High serum fosfomycin levels prevented renal lysosomal accumulation of amikacin, possibly because of the interference of urinary fosfomycin with the endocytosis of proximal tubular cells. These characteristics may explain the effect of fosfomycin in protecting against amikacin nephrotoxicity.
研究了通过腹腔内、肌肉内或口服途径预先或同时给予磷霉素对大鼠阿米卡星药代动力学的影响。联合给予磷霉素可延长阿米卡星从腹腔的吸收。高血清磷霉素水平可防止阿米卡星在肾溶酶体中蓄积，这可能是由于尿中磷霉素干扰近端肾小管细胞的内吞作用所致。这些特性可能解释了磷霉素预防阿米卡星肾毒性的作用机制。
