阿米卡星、妥布霉素和庆大霉素在大鼠肾脏中的蓄积
Renal accumulation of amikacin, tobramycin and gentamycin in the rat.
作者信息
Nieminen L, Kasanen A, Kangas L, Sairio E, Anttila M
出版信息
Experientia. 1978 Oct 15;34(10):1335-6. doi: 10.1007/BF01981456.
PMID:738411
Abstract
Free and total concentrations of amikacin, tobramycin and gentamycin were measured separately in the rat kidney after equal weight by weight doses. The accumulation of aminoglycosides followed the order amikacin less than tobramycin less than gentamycin. The ratio between free and total aminoglycosides was similar (about 0.6) in all 3 aminoglycosides and independent on the length of administration.
摘要
按重量给予等量剂量后，分别测定大鼠肾脏中阿米卡星、妥布霉素和庆大霉素的游离浓度和总浓度。氨基糖苷类药物的蓄积顺序为阿米卡星＜妥布霉素＜庆大霉素。在所有3种氨基糖苷类药物中，游离氨基糖苷类与总氨基糖苷类的比例相似（约为0.6），且与给药时长无关。
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