Rousseau E P, van de Ven A P, van Steenhoven A A, Seroo J M
J Biomech. 1984;17(2):145-53. doi: 10.1016/0021-9290(84)90132-5.
In this paper an equipment is described for the loading of heart valve prostheses under physiological pressure conditions at a frequency of 10 Hz. The system consists essentially of two reservoirs between which a housing is mounted for holding the valve prosthesis. The reservoirs are partly filled with liquid. The physiological pressure variation across the valve is obtained by pressure control within the two reservoirs. A phase difference between the pressures in the two reservoirs compensates for the mass-inertia effects which normally occur at these high frequencies. The system without a valve has been analysed on the basis of simplified relationships between pressure and flow. The predicted values for the phase difference between the flow and the pressure curves within the valve housing, have been verified experimentally for various values of phase difference and amplitude ratios of the pressure variations within the reservoirs. The agreement between theory and experiment is fair. For the system with a valve the experimentally observed patterns closely resemble the theoretically predicted ones. From experiments with a Björk-Shiley ( 21ABP ) and a Hancock (242-A21) valve prosthesis it is concluded that the valves open and close completely and that the pressure and flow patterns around the valves mimic the essential features of the in-vivo signals.
本文介绍了一种用于在生理压力条件下以10Hz频率加载心脏瓣膜假体的设备。该系统主要由两个储液器组成，在它们之间安装有一个用于容纳瓣膜假体的外壳。储液器部分填充有液体。通过控制两个储液器内的压力来获得瓣膜两端的生理压力变化。两个储液器内压力之间的相位差补偿了通常在这些高频下出现的质量惯性效应。已基于压力与流量之间的简化关系对无瓣膜的系统进行了分析。对于储液器内压力变化的各种相位差值和振幅比，已通过实验验证了瓣膜壳体内流量与压力曲线之间相位差的预测值。理论与实验之间的吻合度尚可。对于有瓣膜的系统，实验观察到的模式与理论预测的模式非常相似。通过对Björk-Shiley（21ABP）和Hancock（242-A21）瓣膜假体进行实验得出结论，瓣膜能完全打开和关闭，并且瓣膜周围的压力和流量模式模拟了体内信号的基本特征。
