Stone E, Leiter L A, Lambert J R, Silverberg J D, Jeejeebhoy K N, Burrow G N
J Clin Endocrinol Metab. 1984 Jul;59(1):139-41. doi: 10.1210/jcem-59-1-139.
Because the exact site of thyroid hormone absorption in man is not known, we assessed the absorption of oral [125I]Na-L-T4 in patients with varying lengths of intact bowel and correlated this absorption with bowel length. Two normal subjects and five patients with surgical bowel resections, all of whom were euthyroid, were studied. Each received a tracer dose of [125I]Na-L-T4 orally, and serial samples of serum were assayed for radioactivity both with and without butanol extraction. The peak serum radioactivity in normal subjects occurred 2 h post ingestion and was 15% and 17% of the administered dose per liter serum and 11% and 13%/liter serum in butanol-extracted serum, respectively. In patients with shortened bowel, the peak radioactivity both in serum and butanol extracted serum was decreased, ranging from 2%-7% and 0%-5%/liter, respectively. There was no absorption of labeled T4 in the patient with a duodenum only. No consistent relationship was found between absorption and bowel length distal to the duodenum.
由于人体甲状腺激素吸收的确切部位尚不清楚，我们评估了不同肠管完整长度患者口服[125I]Na-L-T4的吸收情况，并将这种吸收与肠管长度相关联。研究了两名正常受试者和五名接受过肠道手术切除的患者，所有患者甲状腺功能均正常。每位受试者口服示踪剂量的[125I]Na-L-T4，对血清系列样本进行放射性测定，包括未用丁醇提取和用丁醇提取后的情况。正常受试者血清放射性峰值在摄入后2小时出现，分别为每升血清给药剂量的15%和17%，在用丁醇提取的血清中为每升血清的11%和13%。在肠管缩短的患者中，血清和用丁醇提取血清中的放射性峰值均降低，分别为每升2%-7%和0%-5%。仅保留十二指肠的患者未出现标记T4的吸收。未发现吸收与十二指肠远端肠管长度之间存在一致的关系。
