Case P C, Mitchell A J, Swanson N A, Vanderveen E E, Ellis C N, Headington J T
J Am Acad Dermatol. 1984 Mar;10(3):447-50. doi: 10.1016/s0190-9622(84)80091-2.
The efficacy of the topical allergen squaric acid dibutylester (SADBE) was investigated in the treatment of twenty-six patients with alopecia areata or alopecia totalis. The patients had their disease for a mean duration of 8.3 years (range, 3 months to 27 years). Sensitization was attempted with 2% SADBE in acetone. Five individuals could not be sensitized. The twenty-one sensitized patients were treated with topical applications of 0.001% to 1.0% SADBE in acetone adjusted to produce and maintain dermatitis for an average of 21 weeks. Eleven (52%) had excellent responses consisting of complete regrowth in six and cosmetically acceptable regrowth in five. The average treatment time for regrowth was 11 weeks (range, 5-20 weeks). Ten (48%) had no clinical response after an average of 19 weeks of therapy (range, 4-42 weeks). Topical SADBE is an effective therapy for some patients with long-standing alopecia areata.
研究了局部过敏原二丁基酒石酸（SADBE）治疗26例斑秃或全秃患者的疗效。这些患者的病程平均为8.3年（范围为3个月至27年）。尝试用2%的SADBE丙酮溶液进行致敏。5人未能致敏。21名致敏患者接受了局部应用0.001%至1.0%的SADBE丙酮溶液治疗，调整剂量以产生并维持皮炎，平均治疗21周。11人（52%）有良好反应，其中6人完全再生，5人再生情况达到美容可接受程度。再生的平均治疗时间为11周（范围为5至20周）。10人（48%）在平均19周的治疗后（范围为4至42周）无临床反应。局部应用SADBE对一些长期斑秃患者是一种有效的治疗方法。
