Chua S H, Goh C L, Ang C B
National Skin Centre, Singapore.
Ann Acad Med Singap. 1996 Nov;25(6):842-7.
In this prospective, double-sided patient-controlled therapeutical trial involving 20 patients with alopecia areata, we investigated the efficacy of topical acid dibutylester (SADBE) in the treatment of alopecia areata. Sensitisation was achieved with 2% SADBE in acetone followed by weekly application of topical SADBE to designated alopecia sites for 20 weeks. Untreated alopecia sites on the same patient acted as controls. Nineteen of the twenty patients completed 20 weeks of treatment. On the SADBE treated sites, excellent response (> 75% hair regrowth) was observed in 68% (13/19) of patients at the end of 20 weeks of treatment. On the untreated control sites, the corresponding figure was 11% (2/19). The difference in response between SADBE treated and untreated sites was statistically significant (P < 0.001). Mean onset of hair regrowth was 6 weeks after starting treatment. Patients with duration of alopecia 12 months or longer fared poorer compared with patients with a shorter duration of the disease. The extent of involvement did not appear to influence treatment outcome. Side effects were mainly local and were mainly local and were well tolerated. At 6 months follow-up, 33% (2/6) of responders with alopecia totalis relapsed compared to 11% (19) of those with patchy alopecia areata. We conclude that topical immunotherapy with SADBE is effective in inducing hair regrowth in alopecia areata.
在这项涉及20名斑秃患者的前瞻性、双侧患者自控治疗试验中，我们研究了外用二丁酯酸（SADBE）治疗斑秃的疗效。用2%的SADBE丙酮溶液致敏，随后每周将外用SADBE涂抹于指定的斑秃部位，持续20周。同一患者未治疗的斑秃部位作为对照。20名患者中有19名完成了20周的治疗。在接受SADBE治疗的部位，治疗20周结束时，68%（13/19）的患者出现了极佳的反应（头发再生>75%）。在未治疗的对照部位，相应的数字为11%（2/19）。SADBE治疗部位与未治疗部位的反应差异具有统计学意义（P<0.001）。头发再生的平均开始时间为开始治疗后6周。与病程较短的患者相比，病程12个月或更长时间的患者疗效较差。受累程度似乎不影响治疗结果。副作用主要是局部的，耐受性良好。在6个月的随访中，全秃患者中有33%（2/6）的反应者复发，而斑秃患者中有11%（1/9）复发。我们得出结论，外用SADBE免疫疗法在诱导斑秃患者头发再生方面是有效的。
