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两种用于研究大鼠大脑皮层切片神经递质释放的灌流系统的比较。

Comparison of two superfusion systems for study of neurotransmitter release from rat cerebral cortex slices.

作者信息

Korpi E R, Oja S S

出版信息

J Neurochem. 1984 Jul;43(1):236-42. doi: 10.1111/j.1471-4159.1984.tb06701.x.

DOI:10.1111/j.1471-4159.1984.tb06701.x
PMID:6726249
Abstract

Depolarization-induced release of [3H]gamma-aminobutyric acid (GABA) and [3H]noradrenaline (NA) from rat cerebral cortex slices was studied in two superfusion systems: one with stationary and the other one with continuously shaken slice compartments. Calcium-dependent depolarization-induced release of GABA and NA could be demonstrated only with shaken slices. GABA, but not NA, could also be released by high K+ media and veratridine from stationary slices. Synaptic transmitter releasing mechanisms are apparently damaged in stationary slices, possibly due to impaired energy metabolism.

摘要

在两种灌流系统中研究了去极化诱导大鼠大脑皮层切片释放[3H]γ-氨基丁酸（GABA）和[3H]去甲肾上腺素（NA）的情况：一种是切片室固定的系统，另一种是切片室持续振荡的系统。仅在振荡切片中可证实钙依赖性去极化诱导的GABA和NA释放。高钾培养基和藜芦碱也可从固定切片中释放GABA，但不能释放NA。固定切片中的突触递质释放机制显然受损，可能是由于能量代谢受损所致。

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Comparison of two superfusion systems for study of neurotransmitter release from rat cerebral cortex slices.两种用于研究大鼠大脑皮层切片神经递质释放的灌流系统的比较。
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