Rusoff A C
J Neurosci. 1984 Jun;4(6):1414-28. doi: 10.1523/JNEUROSCI.04-06-01414.1984.
The optic nerve of many perciform fish is ribbon-shaped, and axons from ganglion cells in specific parts of the retina are consistently found in specific places in this ribbon. I utilized this organization to fill selected groups of axons with horseradish peroxidase. I then traced these groups of axons through the nerve and across the tectum to their terminal arbors. The paths of the axons suggest that axons use a number of different mechanisms to guide them to their correct terminal sites. At some points they appear simply to grow along the surface created by earlier axons, but at other points they seem to be using cues more complex than simple mechanical guidance. In addition, I have demonstrated that for every anulus of ganglion cells on the retina there is an anulus of terminal arbors on the tectum. With time the terminals in a given anulus must move caudally to keep the retinotopic map centered on the tectum while the tectum continues growing nonsymmetrically . I have shown both that the anuli of terminals do remain roughly centered on the tectum and that the predicted pattern of terminal movement is visible on the tecta of perciform fish.
许多鲈形目鱼类的视神经呈带状，视网膜特定部位的神经节细胞发出的轴突始终位于这条带状结构的特定位置。我利用这种组织结构，用辣根过氧化物酶填充选定的轴突群。然后，我追踪这些轴突群通过神经并穿过顶盖到达它们的终末分支。轴突的路径表明，轴突利用多种不同机制引导它们到达正确的终末位点。在某些点上，它们似乎只是沿着早期轴突形成的表面生长，但在其他点上，它们似乎在利用比简单机械引导更复杂的线索。此外，我已经证明，视网膜上的每个神经节细胞环在顶盖上都有一个终末分支环。随着时间的推移，给定环中的终末必须向尾侧移动，以保持视网膜拓扑图以顶盖为中心，而顶盖继续不对称生长。我已经表明，终末环确实大致以顶盖为中心，并且在鲈形目鱼类的顶盖上可以看到预测的终末移动模式。
