Slutsky R A, Higgins C B
J Nucl Med. 1984 May;25(5):581-91.
Pulmonary fluid volumes (PBV = lung blood volume; EVLW = extravascular lung water) were examined to define the effects of oleic acid injury and then to examine the relationship between edema formation and accumulation of pulmonary thallium. In six dogs, pulmonary fluid compartments were monitored during the induction of pulmonary injury by oleic acid (0.15 cc/kg i.v.). By 30 min after the injection, EVLW had doubled (p less than 0.01); it continued to increase slowly for 180 min, whereas PBV declined. In six anesthetized dogs, we made similar measurements in an identical preparation and compared pulmonary fluid volumes with pulmonary counts derived from sequential thallium (1-1.3 mCi) scintigrams obtained after the injection of oleic acid (0.12-0.15 ml/kg). Measures of EVLW and PBV were obtained sequentially along with thallium scintigrams. There was a linear relationship between EVLW and pulmonary counts alone, or when pulmonary counts were normalized to myocardial activity. We conclude that sequential thallium scintigrams provide useful information about the degree of change of EVLW over time in a model of noncardiogenic pulmonary edema.
检测肺液体容量（PBV = 肺血容量；EVLW = 血管外肺水）以确定油酸损伤的影响，进而研究水肿形成与肺铊蓄积之间的关系。在6只犬中，通过静脉注射油酸（0.15 cc/kg）诱导肺损伤过程中监测肺液体腔室。注射后30分钟，EVLW增加了一倍（p < 0.01）；在180分钟内持续缓慢增加，而PBV下降。在6只麻醉犬中，我们在相同的制备条件下进行了类似测量，并将肺液体容量与注射油酸（0.12 - 0.15 ml/kg）后获得的连续铊（1 - 1.3 mCi）闪烁扫描图得出的肺计数进行比较。同时依次获取EVLW和PBV的测量值以及铊闪烁扫描图。单独的EVLW与肺计数之间，或者当肺计数根据心肌活性进行标准化时，存在线性关系。我们得出结论，在非心源性肺水肿模型中，连续铊闪烁扫描图可提供有关EVLW随时间变化程度的有用信息。
