Bray D L, Briggs G M
J Nutr. 1984 May;114(5):920-8. doi: 10.1093/jn/114.5.920.
These experiments were conducted to investigate the effects of high oral intakes of ascorbic acid on bone metabolism in young guinea pigs and to inquire into the mechanism mediating these effects. Male guinea pigs 14 days old fed 8.7% of ascorbic acid for 6 weeks had decreased bone density and decreased urinary hydroxyproline compared to control animals fed 0.2% of ascorbic acid. To assess whether these changes were due to the acidity of the diet or to vitamin activity, salts of ascorbic acid, salts of erythorbic acid and free erythorbic acid were fed. There were no significant bone changes in any of these groups. The results strongly indicate that the acidity of ascorbic acid plays a part in the decrease in bone density but do not rule out that some other metabolic property specific to ascorbic acid may also be implicated.
进行这些实验是为了研究高口服剂量抗坏血酸对幼年豚鼠骨骼代谢的影响，并探究介导这些影响的机制。与喂食0.2%抗坏血酸的对照动物相比，14日龄雄性豚鼠喂食8.7%抗坏血酸6周后，骨密度降低，尿羟脯氨酸减少。为了评估这些变化是由于饮食的酸度还是维生素活性引起的，喂食了抗坏血酸盐、异抗坏血酸盐和游离异抗坏血酸。这些组中均未出现明显的骨骼变化。结果强烈表明，抗坏血酸的酸度在骨密度降低中起作用，但不排除抗坏血酸特有的其他一些代谢特性也可能起作用。
