Thornber J M, Eckhert C D
J Nutr. 1984 Jun;114(6):1070-5. doi: 10.1093/jn/114.6.1070.
The procedure of rearing rats on high sucrose diets has been used in some laboratories as a drug-free model to induce retinal vascular-bed damage resembling diabetic retinopathy. Examination of dietary salt mixes used in laboratories reporting success with this model revealed that two essential elements, chromium and selenium, were not included. The present study evaluated the effect of supplementing a high sucrose diet, reported to induce retinopathy, with chromium and Selenium supplementation significantly reduced the number of acellular collapsed capillary strands within arterial-venous capillary networks. The addition of chromium to the high sucrose diet resulted in lower fasting blood glucose and a smaller rise in its level following an oral dose. Little or no retinal vascular damage was apparent in rats fed the high sucrose diet supplemented with chromium, selenium and additional corn oil. Of the two elements, only supplementation with Se protected the retinal capillaries from damage.
在一些实验室中，用高蔗糖饮食饲养大鼠的方法被用作一种无药物模型，以诱导类似于糖尿病视网膜病变的视网膜血管床损伤。对报告使用该模型取得成功的实验室所使用的膳食盐混合物进行检查后发现，其中不包含两种必需元素，即铬和硒。本研究评估了在据报道会诱发视网膜病变的高蔗糖饮食中添加铬和硒的效果，补充铬和硒显著减少了动静脉毛细血管网络内无细胞塌陷毛细血管束的数量。在高蔗糖饮食中添加铬可降低空腹血糖水平，且口服一剂后血糖水平的升高幅度较小。在喂食添加了铬、硒和额外玉米油的高蔗糖饮食的大鼠中，几乎没有明显的视网膜血管损伤。在这两种元素中，只有补充硒可保护视网膜毛细血管免受损伤。
