Azibi M, Draguet-Brughmans M, Bouche R
J Pharm Sci. 1984 Apr;73(4):512-5. doi: 10.1002/jps.2600730420.
A comparison of X-ray powder diffraction patterns, IR spectra, and crystal structures of structurally related compounds belonging to the butyrophenone family has been undertaken to obtain information about the elements of chemical structure which predispose a substance to exhibit polymorphism. Five butyrophenones, differing by the nature of only one substituent, were selected. After crystallization from 15 solvents, it appears that two compounds of the group exhibit more than one crystalline form. An explanation of the absence of polymorphism in the other compounds of the group is proposed and discussed.
为了获得有关使物质易于呈现多晶型的化学结构元素的信息，对属于丁酰苯家族的结构相关化合物的X射线粉末衍射图谱、红外光谱和晶体结构进行了比较。选择了仅在一个取代基性质上不同的五种丁酰苯。从15种溶剂中结晶后，该组中的两种化合物似乎呈现出不止一种晶型。对该组中其他化合物不存在多晶型现象提出并讨论了解释。
