Datsiuk N M, Kucheras R V, Rurik V D, Gudz' S P, Kostruba M F, Kremenetskaia S Ia
Mikrobiologiia. 1978 May-Jun;47(3):451-5.
The content of flavins and vitamin B12 was studied in the cultures of Propionibacterium shermanii. The limited ability of propionic bacteria to synthesize 5,6-dimethylbenzimidazole, the nucleotide base in the true forms of vitamin B12, was found to be caused by a deficiency of the biogenetic precursor (riboflavin). Exogenous 5,6-dimethylbenzimidazole had no effect on the processes of flavinogenesis. In the absence of the nucleotide base, the yield of the true forms of vitamin B12 increased upon aeration of cultures which were grown for four days on an iron-deficient medium in the anaerobic conditions.
对谢氏丙酸杆菌培养物中的黄素和维生素B12含量进行了研究。发现丙酸杆菌合成维生素B12真实形式中的核苷酸碱基5,6-二甲基苯并咪唑的能力有限，是由生物合成前体（核黄素）缺乏所致。外源性5,6-二甲基苯并咪唑对黄素生成过程没有影响。在缺乏核苷酸碱基的情况下，在厌氧条件下于缺铁培养基上培养四天的培养物通气后，维生素B12真实形式的产量增加。
