Bykhovsky V Y, Zaitseva N I, Gruzina B D, Malyarova Z A, Ponomaryova G M, Yavorskaya A N
Prikl Biokhim Mikrobiol. 1975 Mar-Apr;11(2):179-84.
The influence of B12-CN, B12-OH, coenzyme B12, factor III and factor B on the synthesis of vitamin B12 and porphyrins by different strains of P. shermanii was investigated. Neither compound inhibited the development of propionic bacteria or suppressed porphyrin formation. All nucleotide containing analogues of vitamin B12 produced a strong repressive effect on the synthesis of corrinoid compounds regardless of the modifications in the upper and lower cobalt ligands. Factor B containing no nucleotide moiety did not show this effect. It is suggested that the nucleotide moiety of the vitamin B12 molecule is responsible for the binding of vitamin to protein aporepressor.
研究了钴胺素（B12-CN）、羟基钴胺素（B12-OH）、辅酶B12、因子III和因子B对不同谢氏丙酸杆菌菌株合成维生素B12和卟啉的影响。这些化合物均未抑制丙酸杆菌的生长或抑制卟啉的形成。所有含核苷酸的维生素B12类似物，无论其上下钴配体如何修饰，均对类咕啉化合物的合成产生强烈的抑制作用。不含核苷酸部分的因子B未表现出这种作用。提示维生素B12分子的核苷酸部分负责维生素与蛋白质无活性阻遏物的结合。
