Powers T A, Stone W J, Witt W S, Killion L T, Patton J A
J Urol. 1984 Jul;132(1):175-8. doi: 10.1016/s0022-5347(17)49514-0.
In previous studies using dogs whose renal function was rendered asymmetric by unilateral infarction or partial ureteral obstruction, the efficacy of technetium-99m diethylenetriamine pentaacetic acid and dimercaptosuccinic acid in the measurement of differential renal function was demonstrated. The present study was undertaken to determine if technetium-99m glucoheptonate could also be used to quantitate differential renal function in these conditions. Five dogs with partial ureteral obstruction, 4 with segmental infarction and 2 with ipsilateral combination of both were studied. Seven to 10 days following these interventions the animals were given a bolus injection of 10 mCi Tc-99m glucoheptonate. This was acquired in the posterior projection on a minicomputer at 2 seconds/frame for 3 minutes. Static images were obtained anteriorly and posteriorly between 3 and 5 hours postinjection. The following day iothalamate and creatinine clearances were measured by ureteral catheterization. There was good correlation between differential function calculated from the 1 to 3 minute portion of the bolus study and that determined by the ureteral catheter studies, r greater than 0.99. Correlations based on the static images were less satisfactory due to pelvic retention in the obstructed animals, r = 0.73. We conclude that technetium-99m glucoheptonate may be used to determine differential renal function.
