Ziessman H A, Balseiro J, Fahey F H, Le T V, Dubiansky V
AJR Am J Roentgenol. 1987 May;148(5):889-93. doi: 10.2214/ajr.148.5.889.
Differential renal function was calculated by using 99mTc-glucoheptonate (Tc-GH) in 51 patients. Computer-acquired background-corrected individual renal function was calculated by using both the 1-3-min uptake counts and the 2-4-hr delayed static counts. The degree of correlation between the two was high (r = .96). An equally high correlation was noted in 16 children who were 12 years old or younger, in 15 patients with renal size disparity greater than 60/40%, and in six patients with abnormal creatinine clearances. Ten patients had a 30-min dynamic 99mTc-DTPA study followed immediately by the injection of Tc-GH and acquisition of delayed static images 2-4 hr later. A high degree of correlation (r = .99) was seen between the 1-3-min differential function obtained by using Tc-DTPA and the 2-4-hr delayed differential function obtained by using Tc-GH. This study shows that Tc-GH is a clinically useful and valid tool for calculation of differential renal function and that Tc-GH combines many of the best aspects of Tc-DTPA and Tc-DMSA.
采用99m锝-葡庚糖酸盐（Tc-GH）对51例患者进行了分肾功能测定。利用1-3分钟摄取计数和2-4小时延迟静态计数，通过计算机获取背景校正后的个体肾功能。两者之间的相关性很高（r = 0.96）。在16名12岁及以下儿童、15名肾大小差异大于60/40%的患者以及6名肌酐清除率异常的患者中，也观察到了同样高的相关性。10名患者先进行了30分钟的动态99m锝-二乙三胺五醋酸（Tc-DTPA）研究，随后立即注射Tc-GH，并在2-4小时后采集延迟静态图像。通过使用Tc-DTPA获得的1-3分钟分肾功能与通过使用Tc-GH获得的2-4小时延迟分肾功能之间存在高度相关性（r = 0.99）。本研究表明，Tc-GH是一种计算分肾功能的临床有用且有效的工具，并且Tc-GH结合了Tc-DTPA和Tc-二巯基丁二酸（Tc-DMSA）的许多最佳方面。
