X线诱导的甲状腺腺癌
X-ray induced thyroid adenocarcinoma.
作者信息
Rosen P
出版信息
Med Hypotheses. 1984 Apr;13(4):381-4. doi: 10.1016/0306-9877(84)90070-7.
A comparison is made of the x-ray induced thyroid adenocarcinoma in the rat by the in-vitro, in-vivo method of Clifton et al. with previous data of Doniach on in-vivo irradiation in whole animals. The Clifton data consists of only one point at 500 rad. I have assumed that the probability of transformation per viable cell from 0 to 500 rad is proportioned to dose and that at higher doses, it is proportional to dose squared. The fraction of rats developing adenocarcinoma agrees with the data of Doniach at 500 and 1100 rads. The rest of the data is filled in by calculation.
将克利夫顿等人的体外和体内方法诱导大鼠产生的X射线诱发甲状腺腺癌，与多尼亚克之前关于对整个动物进行体内照射的数据进行了比较。克利夫顿的数据仅包括500拉德这一个点。我假定从0到500拉德每个活细胞的转化概率与剂量成正比，而在更高剂量下，它与剂量的平方成正比。患腺癌的大鼠比例在500和1100拉德时与多尼亚克的数据相符。其余数据通过计算填补。
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