Robustelli della Cuna G, Zibera C, Fortunati D, Pavesi L, Preti P, Knerich R, Adinolfi D
Minerva Med. 1984 May 19;75(21):1287-92.
Recently the presence of steroid hormone receptors (SHR) have been reported in a series of nervous system human tumors, mainly in meningiomas. The possibility of characterizing brain tumors deserves attention because of the poor knowledge of endocrine-related behaviour of such tumors. The reliability of biochemical characterization of various receptor types should allow for better understanding of biological profile of primary and metastatic brain tumor, together with new avenues for combined modality treatment. In the future the highest priority might be assigned to the definition of the cut-off value of positivity for single receptors and to the receptor-endocrine modulation complex relationship for individual patients. A clear definition of the role of SHR in human brain tumors might improve our therapeutic potentials.
最近，一系列神经系统人类肿瘤中已报道存在类固醇激素受体（SHR），主要是在脑膜瘤中。鉴于对此类肿瘤内分泌相关行为了解甚少，对脑肿瘤进行特征描述的可能性值得关注。各种受体类型生化特征描述的可靠性应有助于更好地理解原发性和转移性脑肿瘤的生物学特性，以及为联合治疗提供新途径。未来，可能应将最高优先级赋予确定单个受体阳性的临界值以及确定个体患者受体 - 内分泌调节的复杂关系。明确SHR在人类脑肿瘤中的作用可能会提高我们的治疗潜力。
