Walther C, Schiebe M, Voigt K H
Neurosci Lett. 1984 Mar 9;45(1):99-104. doi: 10.1016/0304-3940(84)90336-7.
Neurally evoked contractions of the locust jumping muscle are potentiated by the molluscan cardioexcitatory peptide (FMRFamide) and related peptides. This effect is due to a synaptic and a non-synaptic action of the peptides: (1) excitatory synaptic potentials are increased; (2) excitation-contraction coupling becomes more efficient, as indicated by an increased strength of potassium contractures. Octopus heptapeptide (YGGFMRFamide), which contains the entire enkephalin structure (YGGFM), is 100 times more potent than FMRFamide. Structure-activity studies indicate that the observed actions are not mediated by opioid receptors but are dependent on the C-terminal structure of the peptides.
蝗虫跳跃肌肉的神经诱发收缩可被软体动物心脏兴奋肽（FMRF酰胺）及相关肽增强。这种效应归因于这些肽的突触和非突触作用：（1）兴奋性突触电位增强；（2）兴奋-收缩偶联变得更高效，这表现为钾离子挛缩强度增加。含有完整脑啡肽结构（YGGFM）的章鱼七肽（YGGFMRF酰胺）比FMRF酰胺的效力强100倍。构效关系研究表明，观察到的作用不是由阿片受体介导的，而是取决于这些肽的C末端结构。
