Warbrick E V, Rees H H, Howells R E
Department of Parasitology, Liverpool School of Tropical Medicine, UK.
Parasitol Res. 1992;78(3):252-6. doi: 10.1007/BF00931735.
Immunocytochemical techniques were used to detect FMRFamide-like immunoreactivity in adults of the filarial nematodes Dirofilaria immitis and Brugia pahangi. An FMRFamide-like peptide was also located in third- and fourth-stage larvae of D. immitis. Positive immunoreactivity was observed in all parasites examined, irrespective of developmental stage. The major areas of positive immunoreactivity were located in the anterior nerve ring, lateral/dorso-ventral nerves, cephalic papillary ganglia and lateral ganglia. No staining was seen in the intestine or gonads of any parasite. These results indicate that filarial worms possess a peptidergic component in their nervous system. The possible role of an FMRFamide-like peptide in the control of certain physiological events is discussed.
免疫细胞化学技术被用于检测丝虫纲线虫犬恶丝虫和彭亨布鲁线虫成虫中类FMRF酰胺免疫反应性。一种类FMRF酰胺肽也存在于犬恶丝虫的第三期和第四期幼虫中。在所检查的所有寄生虫中均观察到阳性免疫反应，无论其发育阶段如何。阳性免疫反应的主要区域位于前神经环、侧/背腹神经、头部乳头神经节和侧神经节。在任何寄生虫的肠道或性腺中均未观察到染色。这些结果表明丝虫在其神经系统中具有肽能成分。文中讨论了类FMRF酰胺肽在控制某些生理事件中的可能作用。
