脑脊液中的神经元特异性烯醇化酶：可能是海藻酸损伤中神经元损伤的指标。

Neuron-specific enolase in cerebrospinal fluid: a possible indicator of neuronal damage in kainic acid lesions.

作者信息

Steinberg R, Scarna H, Pujol J F

出版信息

Neurosci Lett. 1984 Mar 23;45(2):147-50. doi: 10.1016/0304-3940(84)90090-9.

Abstract

The presence of the neuron specific enolase (NSE) has been tested by sandwich enzyme immunoassay in cerebrospinal fluid (CSF) of rats after intrastriatal injection of various amounts of kainic acid (KA). Incremental release of NSE was observed in CSF for increasing concentrations of injected KA. Still, a significant decrease of NSE striatal content was detected only with the two maximal amounts of KA infused. These data indicate that measurements of NSE in CSF might be a more sensitive index of neuronal damage than the actual assay within the tissue, and also present the advantage of being a non-invasive method of investigation.

摘要

通过夹心酶免疫测定法检测了大鼠纹状体内注射不同剂量的 kainic acid（KA）后脑脊液（CSF）中神经元特异性烯醇化酶（NSE）的存在情况。随着注射 KA 浓度的增加，CSF 中 NSE 的释放量逐渐增加。然而，仅在注入两种最大剂量的 KA 时，才检测到纹状体中 NSE 含量的显著降低。这些数据表明，CSF 中 NSE 的测量可能是比组织内实际检测更敏感的神经元损伤指标，并且还具有作为非侵入性研究方法的优势。