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通过向猴子的豆状核注射γ-氨基丁酸拮抗剂所产生的实验性舞蹈手足徐动症。

Experimental choreoathetosis produced by injection of a gamma-aminobutyric acid antagonist into the lentiform nucleus in the monkey.

作者信息

Jackson A, Crossman A R

出版信息

Neurosci Lett. 1984 Apr 20;46(1):41-5. doi: 10.1016/0304-3940(84)90196-4.

DOI:10.1016/0304-3940(84)90196-4
PMID:6728327
Abstract

An experiment is reported in which injections of the gamma-aminobutyric acid antagonist bicuculline into the lentiform nucleus of the monkey gave rise to a contralateral choreoathetoid dyskinesia. Evidence was obtained of functional heterogeneity between the dorsal and ventral lentiform nucleus, in that only injections into its ventral part gave rise to dyskinesia.

摘要

据报道，一项实验中，向猴子的豆状核注射γ-氨基丁酸拮抗剂荷包牡丹碱会引发对侧舞蹈手足徐动样运动障碍。有证据表明豆状核背侧和腹侧存在功能异质性，因为只有向其腹侧部分注射才会引发运动障碍。

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