Sakaguchi A, LeDoux J E, Sved A F, Reis D J
Neurosci Lett. 1984 Apr 20;46(1):59-64. doi: 10.1016/0304-3940(84)90199-x.
In the present study we sought to determine whether the strain difference in fear reactivity between spontaneously hypertensive rats (SHR) and strain-matched WKY controls might be related to adrenocortical function. SHR and WKY were subjected to adrenalectomy prior to classical fear conditioning. Adrenal cortical steroids were replaced in some animals. Adrenalectomy produced comparable effects on conditioned fear reactivity in SHR and WKY and steroid replacement reversed the effects of adrenalectomy in both strains. However, a larger dose was required to compensate for adrenalectomy in SHR. These date implicate functions related, directly or indirectly, to the adrenal cortex, in the maintenance of the strain difference in fear reactivity.
在本研究中，我们试图确定自发性高血压大鼠（SHR）与品系匹配的WKY对照之间恐惧反应性的品系差异是否可能与肾上腺皮质功能有关。在经典恐惧条件反射之前，对SHR和WKY进行肾上腺切除术。在一些动物中补充肾上腺皮质类固醇。肾上腺切除术对SHR和WKY的条件性恐惧反应性产生了类似的影响，类固醇替代在两个品系中均逆转了肾上腺切除术的影响。然而，在SHR中需要更大的剂量来补偿肾上腺切除术。这些数据表明，直接或间接与肾上腺皮质相关的功能在维持恐惧反应性的品系差异中起作用。
