Dolecek R, Janstová V, Halatová A
Pharmatherapeutica. 1984;3(9):588-91.
Twelve children with pollinosis or bronchial asthma were treated continuously, without interruption, for 6 months with ketotifen (2 mg per day). In the first group of 6 children, growth hormone and blood glucose levels were measured during insulin tolerance tests (-15, 0, 30 and 60 min) and growth hormone levels during the late evening when the children were asleep, before and after 3 and 6 months of treatment. In the second group of 6 children, growth hormone and blood glucose levels were measured during protracted insulin tolerance tests (-15, 0, 15, 30, 45, 60, 75, 90, 105 and 120 min) at the same periods. The results showed that the growth hormone increases and blood glucose decreases were generally the same before and during ketotifen treatment. Growth rate and weight gain in the treated groups were similar to those in control groups of untreated children and were not lower than the average values for Czech children of the same age. Measurements of thyroid stimulating hormone and prolactin levels showed that these also wer not altered during long-term ketotifen administration.
12名患有花粉症或支气管哮喘的儿童连续6个月不间断地接受了酮替芬治疗（每日2毫克）。在第一组6名儿童中，于治疗3个月和6个月前后，在胰岛素耐量试验期间（-15、0、30和60分钟）测量生长激素和血糖水平，并在儿童入睡后的深夜测量生长激素水平。在第二组6名儿童中，在同一时期的延长胰岛素耐量试验期间（-15、0、15、30、45、60、75、90、105和120分钟）测量生长激素和血糖水平。结果显示，在酮替芬治疗前和治疗期间，生长激素增加和血糖降低的情况总体相同。治疗组的生长速率和体重增加与未治疗儿童的对照组相似，且不低于同龄捷克儿童的平均值。促甲状腺激素和催乳素水平的测量结果表明，在长期服用酮替芬期间，这些指标也未发生改变。
