Thompson D M, Moerschbaecher J M
Pharmacol Biochem Behav. 1984 Apr;20(4):619-27. doi: 10.1016/0091-3057(84)90313-7.
In one component of a multiple schedule, patas monkeys acquired a different four-response chain each session by responding sequentially on three keys in the presence of four geometric forms (learning). In the other component, the four-response chain was the same each session (performance). The response chain in each component was maintained by food presentation under a fixed-ratio schedule. Errors produced a brief timeout but did not reset the chain. When phencyclidine was administered alone, overall response rate decreased and percent errors increased in both components with increasing doses. d-Amphetamine alone generally decreased rate and increased errors in learning, but increased rate and had no effect on accuracy in performance. When phencyclidine was administered in combination with d-amphetamine, the phencyclidine dose-effect curves tended to shift to the left as the dose of d-amphetamine was increased. The extent to which the curves shifted, however, depended on both the schedule component and the behavioral measure. For example, with accuracy, the shift was more evident in learning than in performance. Combinations of phencyclidine with a high dose of d-amphetamine generally produced supra-additive effects: i.e., the effects on rate and accuracy were greater than expected from simple addition of the effects of each drug given alone.
在一个多重日程安排的组成部分中，长尾猴在每次实验中通过在四种几何图形出现时依次对三个按键做出反应来习得不同的四反应链（学习阶段）。在另一个组成部分中，每次实验的四反应链都是相同的（表现阶段）。每个组成部分中的反应链通过固定比率的食物呈现来维持。错误会导致短暂的超时，但不会重置反应链。单独给予苯环己哌啶时，随着剂量增加，两个组成部分的总体反应率均下降，错误百分比均增加。单独给予右旋苯丙胺通常会降低学习阶段的反应率并增加错误，但会提高表现阶段的反应率且对准确性无影响。当苯环己哌啶与右旋苯丙胺联合给药时，随着右旋苯丙胺剂量增加，苯环己哌啶的剂量效应曲线往往向左移动。然而，曲线移动的程度取决于日程安排的组成部分和行为指标。例如，就准确性而言，学习阶段的曲线移动比表现阶段更明显。苯环己哌啶与高剂量右旋苯丙胺的组合通常会产生超相加效应：即对反应率和准确性的影响大于单独给予每种药物的效应简单相加所预期的效果。
