Moerschbaecher J M, Thompson D M
J Exp Anal Behav. 1980 May;33(3):369-81. doi: 10.1901/jeab.1980.33-369.
In each of three components of a multiple schedule, monkeys were required to emit a different sequence of four responses in a predetermined order on four levers. Sequence completions produced food on a fixed-ratio schedule. Errors produced a brief timeout. One component of the multiple schedule was a repeated-acquisition task where the four-response sequence changed each session (learning). The second component of the multiple schedule was also a repeated-acquisition task, but acquisition was supported through the use of a stimulus-fading procedure (faded learning). In a third component of the multiple schedule, the sequence of responses remained the same from session to session (performance). At higher doses, d-amphetamine, cocaine, and phencyclidine decreased the overall rate of responding and increased the percent errors in all three components. At lower doses, however, the three drugs produced selective effects on errors. Errors were increased in the learning component at lower doses than those required to disrupt the behavior in the faded-learning component. The performance component tended to be the least sensitive to disruptive drug effects. The data are consistent with the view that stimulus fading can modulate the effects of drugs on acquisition.
在多重日程安排的三个组成部分中，要求猴子在四个杠杆上按照预定顺序发出不同的四个反应序列。序列完成后会按照固定比率的时间表提供食物。出现错误会导致短暂的超时。多重日程安排的一个组成部分是重复获取任务，其中四个反应序列在每个实验环节都会改变（学习）。多重日程安排的第二个组成部分也是重复获取任务，但通过使用刺激消退程序来支持获取过程（消退学习）。在多重日程安排的第三个组成部分中，反应序列在各个实验环节保持不变（表现）。在较高剂量下，右旋苯丙胺、可卡因和苯环己哌啶会降低整体反应率，并增加所有三个组成部分中的错误百分比。然而，在较低剂量下，这三种药物对错误产生了选择性影响。与破坏消退学习组成部分中的行为所需的剂量相比，较低剂量下学习组成部分中的错误增加。表现组成部分往往对药物破坏作用最不敏感。这些数据与刺激消退可以调节药物对获取的影响这一观点一致。
