Aceto M D, Rosecrans J A, Young R, Glennon R A
Pharmacol Biochem Behav. 1984 Apr;20(4):635-7. doi: 10.1016/0091-3057(84)90316-2.
Rats, trained to discriminate the CNS stimulant (+)-amphetamine (1.0 mg/kg) from saline in a two-lever drug administration task, were challenged with various doses of the structurally dissimilar CNS stimulant amfonelic acid. Amfonelic acid was found to substitute for the amphetamine stimulus and was found to be 1.5 times more potent than amphetamine.
在双杠杆给药任务中训练大鼠区分中枢神经系统兴奋剂(+)-苯丙胺(1.0毫克/千克)和生理盐水,然后用不同剂量的结构不同的中枢神经系统兴奋剂安福雷司对其进行激发试验。结果发现安福雷司可替代苯丙胺刺激,且效力比苯丙胺强1.5倍。