ten Velde G P, Kreukniet J
Respiration. 1984;45(2):131-8. doi: 10.1159/000194609.
The histamine inhalation provocation test (HIP) was followed during 5 weeks. This test was performed four (1 patient) or five times under standardized conditions in a group of 21 asthmatic patients. The HIP was performed with increasing concentrations of histamine phosphate produced by a 'Wiesbadener Doppelinhalator'. The HIP was called positive if there was a drop of 15% of the initial FEV1. 12 out of 21 patients (57%) showed a sufficient reproducibility. For the whole group of patients there hardly was a variability of the mean absolute concentration of histamine to produce a positive test, but individual patients showed a wide spread. Furthermore, the correlation between the initial value of the FEV1 and the bronchial response seemed to be highly significant (p less than 0.0001). It is concluded that the HIP is not always reproducible within a short period and that the hyperreactivity of the airways is correlated to the initial value of the FEV1.
在5周内对组胺吸入激发试验（HIP）进行了跟踪。在一组21名哮喘患者中，在标准化条件下对该试验进行了4次（1名患者）或5次。使用“威斯巴登双筒雾化器”产生的浓度递增的磷酸组胺进行HIP。如果第一秒用力呼气量（FEV1）下降15%，则称HIP为阳性。21名患者中有12名（57%）显示出足够的可重复性。对于整个患者组，产生阳性试验的组胺平均绝对浓度几乎没有变异性，但个体患者显示出很大差异。此外，FEV1的初始值与支气管反应之间的相关性似乎非常显著（p小于0.0001）。得出的结论是，HIP在短时间内并非总是可重复的，并且气道高反应性与FEV1的初始值相关。
