Behrisch H W, Elsner R
Respir Physiol. 1984 Feb;55(2):239-54. doi: 10.1016/0034-5687(84)90025-2.
The activities of the glycolytic enzymes were determined in heart, liver, kidney cortex and cerebrum from the harbor seal (Phoca vitulina ) and the adult and newborn dog. Activities were similar in the four dog tissues as well as myocardium and brain tissue from both the newborn dog and seal. Most of the enzyme activities were markedly lower in kidney cortex and liver of the seal and the newborn dog, suggesting that the organs which are rendered ischemic in the diving seal or asphyxiated newborn dog have a lowered demand for glycolytic metabolism. This is perceived as an adaptation to prolong the time tissues can rely on anaerobic metabolism. Expression of the enzyme data in a 'similarity criterion' by dividing activity from an organ likely to be perfused during long diving or asphyxia (e.g., heart), by that from one rendered ischemic (e.g., kidney), yields a quotient which provides a convenient indicator of anaerobic potential. Such a treatment would reflect the contribution of a discrete tissue to the total anaerobic demand of the whole animal. The values thus generated for the glycolytic enzymes are generally higher in the seal and the newborn dog than in the adult dog, and suggest an index for determining the capacity of an animal to withstand repeated and variable asphyxia.
测定了斑海豹（Phoca vitulina）以及成年和新生犬心脏、肝脏、肾皮质和大脑中糖酵解酶的活性。在犬的四种组织以及新生犬和海豹的心肌和脑组织中，酶活性相似。海豹和新生犬的肾皮质和肝脏中大多数酶活性明显较低，这表明在潜水的海豹或窒息的新生犬中缺血的器官对糖酵解代谢的需求降低。这被认为是一种适应机制，可延长组织依赖无氧代谢的时间。通过将长时间潜水或窒息期间可能灌注的器官（如心脏）的活性除以缺血器官（如肾脏）的活性，以“相似性标准”表示酶数据，得到一个商数，它提供了一个方便的无氧潜力指标。这种处理方法将反映离散组织对整个动物总无氧需求的贡献。糖酵解酶产生的这些值在海豹和新生犬中通常高于成年犬，这表明该指标可用于确定动物耐受反复和可变窒息的能力。
