一种抗乙酰胆碱受体抗体的单克隆抗独特型抗体的受体样活性。
Receptor-like activity of a monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibody.
作者信息
Lefvert A K, Fulpius B W
出版信息
Scand J Immunol. 1984 May;19(5):485-9. doi: 10.1111/j.1365-3083.1984.tb00958.x.
Abstract
A monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibody from a patient with myasthenia gravis was shown to bind the cholinergic ligand alpha-bungarotoxin. This binding could be inhibited by other cholinergic ligands, both antagonists and agonists. The anti-idiotype was also able to elicit the production of anti-receptor antibodies in mice. Thus, the anti-idiotype had functional properties similar to those of the original antigen, the acetylcholine receptor.
摘要
一种针对重症肌无力患者抗乙酰胆碱受体抗体的单克隆抗独特型抗体，被证明能与胆碱能配体α-银环蛇毒素结合。这种结合可被其他胆碱能配体（包括拮抗剂和激动剂）抑制。该抗独特型抗体还能够在小鼠体内引发抗受体抗体的产生。因此，该抗独特型抗体具有与原始抗原乙酰胆碱受体相似的功能特性。
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