Lefvert A K
Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden.
J Autoimmun. 1988 Feb;1(1):63-72. doi: 10.1016/0896-8411(88)90077-7.
Anti-acetylcholine receptor antibody associated idiotypes were defined by six murine monoclonal antibodies raised against purified receptor antibodies. Four of the monoclonal antibodies bound to idiotopes located within or close to the antigen binding site of the anti-receptor antibodies; the other two monoclonal antibodies were directed against framework determinants. These monoclonal antibodies recognized idiotopes present on immunoglobulins in 14-60% of patients presenting myasthenia gravis, indicating substantial idiotype sharing. These idiotopes were also found in patients with no detectable anti-receptor antibody activity in their serum. In all patients studied, the pattern of idiotypes fluctuated considerably during the course of the disease regardless of clinical symptoms. This suggests continuous modulation of the autoimmune process in myasthenia gravis.
抗乙酰胆碱受体抗体相关独特型由针对纯化受体抗体产生的六种鼠单克隆抗体所定义。其中四种单克隆抗体与位于抗受体抗体抗原结合位点内或附近的独特位结合；另外两种单克隆抗体则针对构架决定簇。这些单克隆抗体识别出14%至60%重症肌无力患者免疫球蛋白上存在的独特位，表明存在大量独特型共享现象。这些独特位在血清中未检测到抗受体抗体活性的患者中也有发现。在所有研究的患者中，无论临床症状如何，独特型模式在疾病过程中均有相当大的波动。这表明重症肌无力自身免疫过程存在持续调节。
