Mombelli G
Schweiz Med Wochenschr. 1984 Apr 14;114(15):524-8.
Administration of heparin by continuous intravenous infusion is, so far as bleeding complications are concerned, safer than intermittent injection. Recurrence of venous thromboembolism during infusion is rare if the APTT is prolonged to 1 1/2-2 1/2 times the control value. The efficacy of low-dose heparin in the primary prevention of venous thromboembolism in medical patients remains unproven. On the other hand, adjusted-dose subcutaneous heparin treatment provides an effective alternative to oral anticoagulants in the long-term treatment of venous thrombosis.
就出血并发症而言，持续静脉输注肝素比间歇性注射更安全。如果活化部分凝血活酶时间（APTT）延长至对照值的1.5 - 2.5倍，输注期间静脉血栓栓塞复发很少见。低剂量肝素在医学患者静脉血栓栓塞一级预防中的疗效尚未得到证实。另一方面，调整剂量的皮下肝素治疗在静脉血栓形成的长期治疗中为口服抗凝剂提供了一种有效的替代方法。
