Tartter P I, Slater G, Papatestas A E, Aufses A H
Surg Gynecol Obstet. 1984 Jun;158(6):569-71.
Two hundred and eighty-three patients were observed for a minimum of 38 months after undergoing resection of Dukes' B2, C1 or C2 classification for carcinoma of the colon and rectum. Cumulative recurrence rates were higher in patients with elevated preoperative serum alkaline phosphatase levels. Site specific recurrence rates revealed a lower incidence of metastases to the liver in patients with elevated preoperative alkaline phosphatase levels. Elevated serum alkaline phosphatase values in patients with carcinoma of the colon may reflect hepatic metastases, but when metastases to the liver are not detected at laparotomy, patients with elevated levels of alkaline phosphatase are at no greater risk of having metastases to the liver develop than patients with normal levels.
对283例接受结肠直肠癌Dukes' B2、C1或C2分期切除术后的患者进行了至少38个月的观察。术前血清碱性磷酸酶水平升高的患者累积复发率更高。部位特异性复发率显示，术前碱性磷酸酶水平升高的患者肝转移发生率较低。结肠癌患者血清碱性磷酸酶值升高可能反映肝转移，但当剖腹手术未发现肝转移时，碱性磷酸酶水平升高的患者发生肝转移的风险并不比正常水平的患者更高。
