Klompje J, Petrelli N J, Herrera L, Mittelman A
Eur J Surg Oncol. 1987 Aug;13(4):345-7.
A retrospective review was undertaken to determine the influence of preoperative alkaline phosphatase levels on the prognosis of patients who had undergone resection of liver metastasis from colorectal adenocarcinoma at Roswell Park Memorial Institute. From March 1967 to March 1985, 26 patients underwent laparotomy who were thought to have solitary liver metastasis. Twenty of these patients were divided into two groups: group A consisted of seven patients who survived at least 24 months without any evidence of disease and were free of disease at the time of this report. Group B consisted of 13 patients who recurred or died from metastases following liver resection. The preoperative levels of alkaline phosphatase clearly showed that an elevated level before surgery was associated with a poor prognosis in the majority of cases. In group A only one of seven patients had an elevated level where seven of 13 patients in group B had elevated preoperative alkaline phosphatase levels. In conclusion, preoperative alkaline phosphatase levels may be helpful in determining the prognosis of patients considered for curative resection of solitary liver metastasis from colorectal carcinoma.
我们进行了一项回顾性研究，以确定术前碱性磷酸酶水平对在罗斯韦尔公园纪念研究所接受结直肠癌肝转移切除术患者预后的影响。1967年3月至1985年3月，26例被认为有孤立性肝转移的患者接受了剖腹手术。其中20例患者被分为两组：A组由7例存活至少24个月且无任何疾病证据且在本报告时无疾病的患者组成。B组由13例肝切除术后复发或死于转移的患者组成。术前碱性磷酸酶水平清楚地表明，大多数病例中术前水平升高与预后不良相关。A组7例患者中只有1例水平升高，而B组13例患者中有7例术前碱性磷酸酶水平升高。总之，术前碱性磷酸酶水平可能有助于确定考虑对结直肠癌孤立性肝转移进行根治性切除患者的预后。
