Carson D J
Lancet. 1977 Apr 23;1(8017):894-7. doi: 10.1016/s0140-6736(77)91212-0.
Data from 30 fatal cases of dextropropoxphene poisoning occurring in Northern Ireland over three years have been studied. All the victims had ingested more than therapeutic amounts, and many had also taken alcohol or other drugs. Most of the deaths were probably suicides. Death occurred very rapidly suggesting that the narcotic effects of dextropropoxyphene predominated, and this may explain the scarcity of clinical reports, It is suggested that many doctors are unaware of the danger of dextropropoxyphene in overdosage and that the problem of dextropropoxyphene poisoning in the United Kingdom has not been fully appreciated. This supposition, if correct, highlights the absence of a satisfactory early-warning system for serious drug effects including death.
对北爱尔兰三年内发生的30例右丙氧芬中毒致死病例的数据进行了研究。所有受害者摄入的剂量均超过治疗量，许多人还同时饮酒或服用了其他药物。大多数死亡可能是自杀所致。死亡发生得非常迅速，表明右丙氧芬的麻醉作用占主导，这或许可以解释临床报告为何稀少。有人认为，许多医生并未意识到右丙氧芬过量服用的危险性，而且联合王国右丙氧芬中毒问题尚未得到充分认识。如果这一推测正确，就凸显出缺乏一个针对包括死亡在内的严重药物不良反应的令人满意的早期预警系统。
