Obafunwa J O, Busuttil A, al-Oqleh A M
Department of Pathology, University of Edinburgh, UK.
Int J Legal Med. 1994;106(6):315-8. doi: 10.1007/BF01224778.
A total of 48 cases of dextropropoxyphene-related deaths that occurred over a 6-year period (1987-1992) in the Lothian and Borders region of Scotland were reviewed. No significant gender difference was found but a significantly greater proportion of the deaths occurred in the urban areas (P < 0.05). Suicide accounted for 81.3% of cases while the other deaths were caused accidentally and involved drug addicts, alcoholics and those who had taken their dextropropoxyphene-containing prescriptions following consumption of alcohol. Overall concomitant alcohol abuse was identified in 41.7% of all the victims. Compound analgesic preparations containing dextropropoxyphene are still widely prescribed and the persistence of deaths from its overdose may suggest the need for stricter prescription control and for educational programmes for users.
对1987年至1992年这6年间在苏格兰洛锡安和边境地区发生的48例右丙氧芬相关死亡病例进行了回顾。未发现显著的性别差异，但城市地区的死亡比例显著更高（P < 0.05）。自杀占病例的81.3%，其他死亡为意外死亡，涉及吸毒者、酗酒者以及饮酒后服用含右丙氧芬处方药物的人。总体而言，在所有受害者中，41.7%被确定存在酗酒问题。含右丙氧芬的复合镇痛制剂仍被广泛处方，其过量服用导致的死亡持续存在，这可能表明需要更严格的处方管控以及针对使用者的教育项目。
