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破伤风毒素和肉毒杆菌A毒素对原代神经细胞培养物中3H-乙酰胆碱释放的抑制作用。

Suppression of 3H-acetylcholine release from primary nerve cell cultures by tetanus and botulinum-A toxin.

作者信息

Bigalke H, Dimpfel W, Habermann E

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1978 Jun;303(2):133-8. doi: 10.1007/BF00508058.

DOI:10.1007/BF00508058
PMID:673020
Abstract

Primary nerve cell cultures derived from embryonic rat central nervous system form [3H]ACh from exogenous [3H]Ch, and release it upon potassium depolarization. Pretreatment of the cultures with botulinum-A toxin or tetanus toxin diminishes the cellular accumulation of [3H]ACh. Poisoning the cultures during the period of [3H]Ch uptake fails to lower [H]ACh formation. Dependent on dosage, both toxins suppress the release of [3H]ACh upon potassium depolarization. Heat-denaturated toxins as well as tetanus toxin preincubated with tetanus antitoxin were without effect.

摘要

源自胚胎大鼠中枢神经系统的原代神经细胞培养物能利用外源性[3H]胆碱形成[3H]乙酰胆碱，并在钾离子去极化时释放它。用肉毒杆菌A毒素或破伤风毒素预处理培养物会减少[3H]乙酰胆碱的细胞积累。在[3H]胆碱摄取期间使培养物中毒并不能降低[3H]乙酰胆碱的形成。根据剂量不同，两种毒素都会抑制钾离子去极化时[3H]乙酰胆碱的释放。热变性毒素以及与破伤风抗毒素预孵育的破伤风毒素均无作用。

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Suppression of 3H-acetylcholine release from primary nerve cell cultures by tetanus and botulinum-A toxin.破伤风毒素和肉毒杆菌A毒素对原代神经细胞培养物中3H-乙酰胆碱释放的抑制作用。
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Tetanus toxin and botulinum A toxin inhibit acetylcholine release from but not calcium uptake into brain tissue.破伤风毒素和肉毒杆菌A毒素抑制脑组织中乙酰胆碱的释放，但不抑制钙的摄取。
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