Doyle J J, Younger R L
Vet Hum Toxicol. 1984 Jun;26(3):201-4.
Five groups of cattle were dosed daily with either 0, 6.3, 7.8, 9.8 and 12.2 mg of lead/kg of body weight for 118 days or for as long as they lived, and tissue concentrations of lead, iron, zinc, copper and manganese were determined post-mortem. Mean intakes of lead for the five groups were 0, 34, 165, 55 and 57 g respectively. Lead accumulated in all tissues of treated animals and was greatest in kidneys and liver. The accumulation of lead and iron in livers of the treated animals appeared to be related to lead intake. The zinc and iron concentrations in liver were significantly increased by the ingestion of lead whereas the copper concentrations in liver and heart and the manganese concentration in kidney were significantly decreased by the ingestion of the lead.
将五组牛每日分别按0、6.3、7.8、9.8和12.2毫克铅/千克体重的剂量给药，持续118天或直至它们死亡，死后测定铅、铁、锌、铜和锰的组织浓度。五组牛的铅平均摄入量分别为0、34、165、55和57克。铅在经处理动物的所有组织中蓄积，在肾脏和肝脏中含量最高。经处理动物肝脏中铅和铁的蓄积似乎与铅摄入量有关。摄入铅会使肝脏中的锌和铁浓度显著升高，而摄入铅会使肝脏和心脏中的铜浓度以及肾脏中的锰浓度显著降低。
