Goranov Kh, Gabrovski P, Zheliazkov S, Popgeorgieva M
Vet Med Nauki. 1984;21(1):43-50.
Experiments were carried out with sheep and cows on the basis of a limited feed ration--the giving of concentrates was discontinued, and the ration of alfalfa hay was replaced with meadow hay and a monensine supplement (at the rate of 20-25 mg for sheep and 250 mg for cows, daily), and nicotinic acid (at 0.8 g and 6.0 g, respectively). Observations revealed that in the course of 6-7 weeks in succession the drop of blood sugar was reduced, and monensine led to a rise of the alkali reserves of the blood by 27 to 41 per cent. Cows with ketonuria (from ++ up to + positive results with the nitroprusside tests) and hydroglycaemia (blood sugar up to 30 mg) were treated with monensine at the rate of 125 mg, in the morning and in the evening or with nicotinic acid at 3 g and the same frequency for 6-7 consecutive days. The symptoms receded to a greater extent (12.1 to 60 per cent) as compared to the process of self-healing for the same time period. In this respect the effect of monensine was better manifested. It was demonstrated that the prophylactic use of these drugs inhibited to a minimum the manifestation of hypoglycaemia and ketonuria.
在限量日粮的基础上，对绵羊和奶牛进行了实验——停止投喂精饲料，用草地干草和莫能菌素补充剂（绵羊每日20 - 25毫克，奶牛每日250毫克）以及烟酸（分别为0.8克和6.0克）替代苜蓿干草日粮。观察发现，连续6 - 7周期间，血糖下降情况有所减轻，莫能菌素使血液碱储备增加了27%至41%。对患有酮尿症（硝普钠试验结果从++到 + 阳性）和低血糖症（血糖高达30毫克）的奶牛，以125毫克的剂量早晚各用一次莫能菌素，或以3克的剂量、相同频率连续6 - 7天使用烟酸进行治疗。与同期自愈过程相比，症状消退程度更大（12.1%至60%）。在这方面，莫能菌素的效果表现得更好。结果表明，预防性使用这些药物可将低血糖症和酮尿症的表现抑制到最低程度。
