Goranov Kh, Atsev G, Gabrovski P, Danov M, Enchev E
Vet Med Nauki. 1983;20(3-4):73-9.
Experiments with normal animals (10 sheep and 15 cows) revealed that the intravenous injection of bovicystan led to a considerable and dependable rise of the blood sugar for 2 to 36 hours the peak being at the 6th hour. The treatment of 95 freshly calved cows on 8 farms with signs of subclinical ketosis (ketonemia 22.4 +/- 1.9 mg%, ketonuria up to dilution of 1:2-1:16 and hypoglycemia 26.7 +/- 2.6 mg%) resulted in a 92.6 per cent total curative effect, consisting in the full inhibition of ketonuria, drop of the ketone bodies in the blood up to 16.5 +/- 1.2 mg%, on an average, and rise of the blood sugar up to 47.7 +/- 1.2 mg%, on an average. In 27.4 per cent of the treated cows ketonuria disappeared after the first injection, in 50.5 per cent - after the second one, and in 14.7 per cent only did ketonuria faded after the third injection of the preparation within a period of 24 hours. At the 48th hour following the last introduction of bovicystan there was an increase in the blood serum level of carotene and lactose, and a decrease in the level of inorganic phosphorus. One to three weeks after treatment with bovicystan in some 27.6 to 33.0 per cent of the cows on 2 of the farms signs of subclinical ketosis reappeared.
对正常动物（10只绵羊和15头牛）进行的实验表明，静脉注射博维斯坦可使血糖在2至36小时内显著且可靠地升高，峰值出现在第6小时。对8个农场的95头刚产犊且有亚临床酮病迹象（酮血症22.4±1.9毫克%，酮尿症高达1:2 - 1:16稀释度，低血糖26.7±2.6毫克%）的奶牛进行治疗，总治愈率达92.6%，表现为酮尿症完全受到抑制，血液中酮体平均降至16.5±1.2毫克%，血糖平均升至47.7±1.2毫克%。在接受治疗的奶牛中，27.4%在首次注射后酮尿症消失，50.5%在第二次注射后消失，仅14.7%在第三次注射该制剂后的24小时内酮尿症才消退。在最后一次注射博维斯坦后的第48小时，血清中胡萝卜素和乳糖水平升高，无机磷水平降低。在其中2个农场，约27.6%至33.0%的奶牛在接受博维斯坦治疗1至3周后，亚临床酮病迹象再次出现。
