Noyez L, Lerut T, Gruwez J A, Bulcke J A
Acta Chir Belg. 1984 Mar-Apr;84(2):61-6.
Myasthenia gravis is an autoimmundisease characterized by muscle fatigability due to a reduction in available acetylcholinereceptors at neuromuscular junction. Although the role of the thymus in the pathophysiology remains obscure, the results of thymectomy are out of discussion. However, controversy continues concerning the indications for thymectomy. In a period of six years and a half, 24 patients underwent a thymectomy. 22 of the patients benefited from the procedure. Their was no relation with sex, age, and severity of the disease; but how sooner we operate, how greater the changes for a total remission. With this results we propose thymectomy as essential in the treatment of myasthenia gravis. We found no relationship between anatomopathological results and these of the thymectomy. But we can confirm that a reduction in the acetylcholine antibodies titer is not essential for clinical benefit.
重症肌无力是一种自身免疫性疾病,其特征是由于神经肌肉接头处可用乙酰胆碱受体减少而导致肌肉疲劳。虽然胸腺在病理生理学中的作用仍不明确,但胸腺切除术的结果是毋庸置疑的。然而,关于胸腺切除术的适应症仍存在争议。在六年半的时间里,24例患者接受了胸腺切除术。其中22例患者从该手术中获益。这与性别、年龄和疾病严重程度无关;但手术越早,完全缓解的机会就越大。基于这些结果,我们建议胸腺切除术是重症肌无力治疗的关键。我们发现解剖病理学结果与胸腺切除术的结果之间没有关联。但我们可以确认,乙酰胆碱抗体滴度的降低对于临床获益并非必不可少。